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Cambridge Cardiac Care Affiliated Publications

Cambridge Cardiac Care is among the nation’s leaders in clinical cardiometabolic research. Investigating the nature of this family of diseases and developing new therapies & novel medical devices, we are committed to doing our part to propel the science and practice of cardiology into the future.

The CHANGE Study: Comprehensive primary pulmonary hypertension assessment & nutritional management

Primary Pulmonary Hypertension (PPH) characterizes systolic pulmonary arterial pressures greater than 40 mm Hg with no known underlying disease or condition causing the elevation. Limited treatments are available for PPH, with the most recent life expectancy estimates remaining below 7 years after diagnosis. In this study, we assessed whether obesity contributes to PPH and the impact of…

THE COMPARATIVE EFFECTS OF BURST EXERCISE VERSUS SUSTAINED EXERCISE ON THE CARDIOMETABOLIC STATUS OF NEWLY DIAGNOSED DIABETIC PATIENTS

Physical activity is an integral part of diabetes rehabilitation. Historically, diabetes rehabilitation has employed low intensity, sustained exercise. Recent studies have demonstrated short-term cardiometabolic benefits of high intensity burst exercise in healthy volunteers. The impacts of burst exercise in diabetics have yet to be adequately assessed. This study compared the impacts of burst…

Subclinical Atrial Fibrillation in Older Patients

Long-term continuous electrocardiographic monitoring shows a substantial prevalence of asymptomatic, subclinical atrial fibrillation (SCAF) in patients with pacemakers and patients with cryptogenic stroke. Whether SCAF is also common in other patients without these conditions is unknown.

Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis

Aortic stenosis (AS) is an active process with similarities to atherosclerosis. The objective of this study was to assess the effect of cholesterol lowering with rosuvastatin on the progression of AS.

Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study

The aim of this study was to describe the association of baseline MAC and aortic valve morphology in asymptomatic patients enrolled in the ASTRONOMER study, a multicentre study to assess the effect of Rosuvastatin on the progression of AS.

Clinical Usefulness of Tissue Doppler Imaging in Patients with Mild to Moderate Aortic Stenosis: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin Study

The objective of this study was to describe both conventional and TDI measurements of diastolic function in asymptomatic patients enrolled in the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin study, a multicenter study to assess the effect of rosuvastatin on the progression of AS.

Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis: The Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) trial

Aortic stenosis (AS) is a common health problem in the western world. Recent studies have suggested that cholesterol lowering may have a salutary effect on the progression of AS. The primary objective of the ASTRONOMER study is to determine whether patients with AS randomized to rosuvastatin will experience less progression in AS severity as measured by aortic…

Human endothelin-1 clearance kinetics revealed by a radiotracer technique

It remains uncertain whether the presence of elevated levels of ET-1 in the setting of disease are secondary to changes in production or clearance or some combination thereof. Using a 125I-labeled ET-1 infusion technique, the volume of distribution and kinetics of clearance of endothelin were described i ET-1 clearance was best described by a three-compartment model, which revealed that ET-1…

Chronic ET-1 Blockade Preserves Myocardial Contractility in Dilated Cardiomyopathy

Immediately after an acute myocardial infarction (AMI) or in models of ischemia–reperfusion injury, cardiac endothelin (ET) system is markedly activated, and plasma levels of ET are increased. In the heart, expression of the main components of the ET system (ET-1 peptide, both receptor subtypes ETA and ETB, though not endothelin converting enzyme) are increased both at the gene level and…

Effects of metals on early life stages of brine shrimp Artemia: a developmental toxicity assay.

The need for simple, fast and inexpensive tests to study metal pollution in the marine environment has become more pressing as utilization of coastal waters increases. To address this concern, the influence of four metals, cupric sulfate, lead nitrate, zinc sulfate and nickel sulfate, on emergence and hatching of the brine shrimp,Artemia, has been assessed. It is apparent from the…

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